Ion channels in nociception (4 h)
Nociceptors are peripheral sensory neurones which respond to painful (noxious) stimuli thanks the expression of nociceptive ion channels. Nociceptors express a unique repertoire of voltage-gated channels, as well as cation channels of the transient receptor potential (TRP), acid-sensing ion channel (ASIC), and purinergic P2X families. The course will focus on the specific properties of nociceptive channels and their role in a number of pain modalities, including inflammatory pain, neuropathic pain, visceral pain, and pain associated to certain pathological conditions, including cancer or migraine
