Protumoral role of myelopoiesis: impact on anti-neoplastic therapy (4 h)
Cancers promote immunological stresses that induce alterations of the myelopoietic output, defined as emergency myelopoiesis, which lead to the generation of different myeloid populations endowed with tumor-promoting activities. New evidence indicates that acquisition of this tumor-promoting phenotype by myeloid cells is the result of a multistep process, encompassing initial events originating into the bone marrow and later steps operating in the tumor microenvironment. The careful characterization of these sequential mechanisms is likely to offer new potential therapeutic opportunities. The course will describe relevant mechanisms of myeloid cell reprogramming that establish immune dysfunctions and promote tumor progression, thus limiting the efficacy of anticancer therapies.
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