Cellular calcium signaling in Health and Disease (8 h)

Human body contains about 1.2 kg of elementary calcium (Ca). The majority of it is immobilized in bones and teeth in a form of phosphate salts, but less than 1% of ionized Ca2+ escapes the trapping and serves as a signaling molecule to conduct and codify signaling information between and inside the cells. Signals conducted by Ca2+ ions as well as proper handling of Ca2+ fluxes inside the cell (called also calcium homeostasis) are fundamental for normal functioning of any cellular type of an organism as many (if not all) cellular processes directly or indirectly depend on Ca2+. When adequate Ca2+ signals are lacking, or when Ca2+ fluxes become too intense, cell or tissue may turn from health to disease. The list of diseases linked to deregulation of Ca2+ homeostasis is impressive and includes genetic and idiopathic diseases from all ategories. Understanding of principles of Ca2+ homeostasis and Ca2+ signaling is important for every person those activity is linked to biology of the cell. In this 8 hours course of “Cellular calcium signaling in Health and Disease” PhD students will learn the mechanisms of maintenance of cellular Ca2+ homeostasis, principles of Ca2+ signaling in healthy and diseased cell and methods used to date to monitor Ca2+ signals inside the cell. The possibility of short practical training in single cell Ca2+ imaging using synthetic Ca2+ probe Fura-2 may also be considered.


D. Lim







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