This interdisciplinary course is targeted at students who wish to learn the basics and challenges of drug screening in information rich cell-based models. Aspects of assay design ranging from cell type choice, readout selection, standardization, miniaturization, high content analysis, will be covered. Moreover, advantages of targeted versus phenotypic assays in drug screening will be discussed. At the end, participants will be challenged in a competition to propose a cell-based assay that could be potentially relevant for their own research projects/interests. Of the thousands of novel compounds that a drug discovery project leads to, only a fraction of these have sufficient ADMET properties to become a clinical candidate. The course is devoted to providing PhD students engaged in the early drug discovery process with the concepts, the strategies and the methodologies that assist the identification of high-quality drug candidates.